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Increased heart rate

When I drink coffee while taking Semaglutide, I notice that my heart beats faster. Is this normal?

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Jonas Williams
Jonas Williams
21 sept. 2025

Actually, this is explained by the mechanism of action of both Semaglutide and caffeine, and is described in an article at https://valhallavitality.com/blog/the-impact-of-coffee-on-semaglutide-treatment-outcomes . Semaglutide can slightly increase your heart rate by affecting stomach hormones, and caffeine further stimulates the cardiovascular system by increasing adrenaline and heart rate. The combination of both factors sometimes causes noticeable discomfort, especially in people who are sensitive to caffeine. The article advises controlling the amount of coffee consumed and even trying to give it up for a few days to see if the heart palpitations decrease. It is also helpful to drink coffee several hours after taking Semaglutide to minimize peak effects on the heart and avoid excessive stimulation. Be sure to discuss these changes with your doctor to adjust the safety regimen of the drug.

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